Ανίχνευση πλαστικών στο ωοθυλακικό υγρό…..

Abstract

Purpose Serum and urinary bisphenol A (BPA) concentrations have been associated negatively with the number of retrieved oocytes after in vitro fertilization (IVF). The impact of BPA upon women with polycystic ovary syndrome (PCOS) and women with tubal factor infertility (TFI), following IVF, was investigated. To this purpose, associations among serum and urinary and follicular fuid (FF) BPA concentrations and the number of retrieved and fertilized oocytes and comparisons between pregnancy rates were evaluated. Methods This was a cross-sectional study conducted at a university-afliated assisted conception unit between January and November 2019, including 93 women of reproductive age (PCOS: 45; TFI: 48) following IVF. Unconjugated FF and serum BPA concentrations and total urinary BPA concentration were measured using a novel gas chromatography–mass spectrometry method. The number of retrieved and fertilized oocytes and pregnancy rate were documented and evaluated. Results The number of oocytes retrieved from PCOS women was greater than that of 21 TFI women, independently of BMI. Lower FF BPA concentrations were found in all PCOS women and in overweight/obese PCOS compared to TFI women (0.50, 0.38, and 1.13 ng/mL, respectively). In TFI women, FF BPA concentrations correlated negatively with the number of retrieved oocytes. Serum and FF and urinary BPA concentrations did not signifcantly afect the number of fertilized oocytes and pregnancy rate in both groups. Conclusion FF BPA concentrations were lower in all PCOS women and in overweight/obese PCOS than in TFI women. In TFI women, FF BPA concentrations correlated negatively with retrieved oocytes. Confrmation of these fndings might lead to moderation of use of BPA-containing products by women undergoing IVF.

 

BPA OOCYTES 2022

Η Ενδοκρινολόγος Ελένη Κούστα έχει εξειδικευθεί στην Αναπαραγωγική Ενδοκρινολογία (Ενδοκρινολογία της γυναίκας) και στην Παιδιατρική Ενδοκρινολογία. Είναι διδάκτωρ του Πανεπιστημίου Αθηνών.